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Diindolylmethane is an androgen antagonist. DIM blocks the effects of testosterone.
Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. Testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. This is one of the ways DIM can help in cases of prostate cancer; the other way is by inhibiting mTOR pathways that lead to cell growth and division but we will discuss mTOR in greater detail later when we discuss muscle hypertrophy. Diindolylmethane as an anti-estrogen The discovery of DIM stems from research on the anticancer potential of a diet high in cruciferous brassica vegetables such as broccoli, broccoli sprouts, radishes, pak choy, kale, brussels sprouts and cabbages.
These foods contain a multitude of beneficial phytonutrients, activated vitamins and cofactors in particular glucosinolates. Glucoraphanin is a stable plant glucosinolate that is converted to the active isothiocyanate, sulforaphane by an enzyme known as myrosinase. Broccoli also contains glucobrassicin, the glucosinolate precursor of indole-3-carbinol (I3C) and subsequently Diindolylmethane (DIM).
Indole-3-carbinol was studied extensively and found to be effective and beneficial for cancers but was shown to be very unstable. DIM was found to be more stable and more suitable for use in supplements. Very low doses of DIM (less than 100mg daily) in combination with other sulforaphanes and necessary cofactors folate and B12 as found in nature can help alter estrogen detoxification pathways in the gut and liver and improve the 2:16 alpha hydroxyl estrone ratios to reduce excessive estrogen activity.
The research on DIM for this purpose is not adequate, with small groups and short durations and is far from convincing. The lack of effect may possibly be due to the need for the other glucosinolates compounds and the cofactors methylated folate and vitamin B12, which are necessary for this pathway.
Diindolylmethane is a phytoestrogen In estrogen deficit DIM increases estrogen activity. Phytoestrogens work to maintain a certain amount of hormonal activity. When testosterone is adequate or high and estrogen is relatively low as seen in males, menopause, andropause, PCOS, “metabolic damage” post comp and in female athletes with low body fat and low estrogen levels; DIM will bind and activate estrogen receptors to increase estrogen activity while blocking the androgen receptors to decrease testosterone activity. Diindolylmethane blocks mTOR Higher doses of DIM act systemically to block anabolic androgens and mTOR pathways. MTOR is necessary for cell growth and for this mechanism DIM is currently being researched as a potential tool for reducing growth of cancer and tumours; this research is still a long way from being able to make any solid anti-cancer claims for DIM. However, it is important for athletes using DIM as part of a muscle building campaign to know that mTOR is the main anabolic pathway necessary for muscle hypertrophy and DIM will also block mTOR stimulation of cell growth.
Mutators are a feature that lets you modify your. Mutators are selected upon entering a game, on the same screen as the level select. Mutators can alter the appearance of your goat, give it new physics properties, or give it special abilities that can be activated with the Special key (R by default, or the Y button on Xbox).
Multiple mutators can be applied at once, though not all mutators work well together. New mutators can be unlocked by completing achievements and by collecting. Some of them, which are not listed here, can only be obtained in DLC maps, like,. Only dirt block and wood block Unlockable Mutators (excluding DLCs) Icon Name Description Unlock Requirement The common Tall Goat can be found on the plains of Africa. The fastest goat in town. Special to blow water out of your head.
Become a goat from outer space! The power of the devil in my hooves. Complete the.
Use your diving powers, Special to fall slowly! Complete the. Come fly with me, let's fly, let's fly away! Special to thrust. Available at start.
Special to summon peasants. Complete the. You are a true fighter! Complete the.
Beep boop Complete the. Stand still and Special repeatedly to charge a spin. Release by pressing Forward. Available at start. Grab stuff by licking then Special to make bombs! Available at start. To speak Dragon, Special Complete the.
![Blocker Blocker](http://i50.tinypic.com/117zew6.jpg)
Complete the. Special to be disgusting! Complete the. Elegant and classy, yes we are.
Elegant, so classy Collect 10. Special to party! Complete the. This goat excels in craftsmanship. Build whatever your heart desires.
Special to build Complete the. (This goat is unavailable in the Xbox/Playstation version of Goat Simulator) This goat is crazy about shopping! Special to activate the rocket-skates!
Special to activate the grappling hook. Complete the. (This goat is unavailable in the Xbox/Playstation version of Goat Simulator) Special hitchhike.
Complete the. Because all games need a good double jump Available at start.